Novel Humanized Mouse Models of ALS Recapitulate the Human Molecular & Pathological Hallmarks of ALS But Overcome the Artifacts Associated with TDP-43 Over-Expression
Time: 10:45 am
day: Day Two Track A AM
Details:
- Overexpression of TDP-43 leads to aggressive phenotypes and potential artifacts that are not related to ALS
- Humanized C9orf72 and TDP-43 mouse models show degeneration, TDP-43 mislocalization, aggregation and mis-splicing of TDP-43 targets
- These models can be used to rapidly screen therapeutics that restore TDP-43 function
