Overcoming Donor-to-Donor Heterogeneity In Vitro Models for ALS: Advancing Precision in Preclinical Research
Time: 11:00 am
day: Conference Day One Track A
Details:
- Identifying and mitigating the genetic and epigenetic variability that complicates distinguishing disease effects from natural donor differences in iPSC models
- Moving beyond single-cell systems to co-cultures and organoids for replicating ALS-relevant tissue microenvironments
- Addressing discrepancies between human TDP-43 biology and animal models to enhance preclinical relevance
- Standardizing quality controls for iPSC-derived models and incorporating scalable multi-cellular systems for robust translational research
