Leveraging Biomarkers to Understand Mitochondrial Dysfunction in ALS: A Neuro-Metabolic Approach
Time: 1:30 pm
day: Conference Day Two Track A PM
Details:
• Exploring biomarkers reflecting mitochondrial energy imbalance in ALS with a focus on shifts from glucose to lipid oxidation
• Discussing early-stage biomarkers identified in ALS animal models (days 20-25), allowing for earlier detection of disease progression
• Showcasing preclinical data on metabolic interventions that restore glucose oxidation highlighting biomarkers used to monitor treatment effects
• Clinical data
• Expanding ALS biomarker panels beyond TDP-43 and NFL to improve early detection and disease monitoring
• Examining how metabolic biomarkers can inform clinical trial endpoints and improved disease progression tracking in ALS
