Amanda Guise

Company: Biogen

Job title: Principal Scientist, Translational Medicine & Discovery Pathology

Seminars:

Unbiased Proteomic Analysis of Clinical Trial CSF Samples to Identify Early Pharmacodynamic Response Signatures Associated with Disease-Modifying Therapies in ALS 1:30 pm

Identification of tofersen PD-response biomarkers in SOD1-ALS VALOR clinical trial CSF via multiplexed quantitative proteomics Significant modulation from baseline abundance observed for 56 proteins in tofersen-treated participants relative to placebo, including proteins with significant changes from baseline as early as 4 weeks post-treatment Orthogonal validation of selected biomarker candidates across independent tofersen-treated cohorts Utility of…Read more

day: Conference Day One Track A PM