Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization

• Differentiation of multiple neuronal & glial cell types using healthy and disease patient derived hiPSCs
• TDP-43 mislocalization and the detection of STMN2a in ALSpatient derived iPSC motor neurons
• Demonstrating the efficacy of these models to improve the discovery of drug targets, the validation of biomarkers and the prediction of preclinical outcomes in drug development

Speakers:

Tetsuya Tanaka

Vice President, Stem Cell Biology

Ricoh Biosciences