Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization
- Differentiation of multiple neuronal & glial cell types using healthy and disease patient derived hiPSCs
- TDP-43 mislocalization and the detection of STMN2a in ALSpatient derived iPSC motor neurons
- Demonstrating the efficacy of these models to improve the discovery of drug targets, the validation of biomarkers and the prediction of preclinical outcomes in drug development