Makoto Tamura
Executive Director Tanabe Pharma
Makoto Tamura, PhD, is the Executive Director of the NeuroDiscovery Lab at Tanabe Pharma America, where he leads advanced neuroscience research and drug discovery programs focused on ALS and other neurodegenerative diseases. His work integrates patient‐derived iPSC models, AI driven platforms, and translational biology to accelerate the development of novel therapeutics. He collaborates widely with academic and industry partners to drive innovation from basic science to clinical impact.
Seminars
Wednesday 3rd June 2026
TDP‑43 LOF–Driven Splicing Signature as a Molecular Classifier for ALS
2:10 pm
- Demonstrate how a TDP‑43 loss‑of‑function–driven alternative splicing signature functions as a mechanism‑based molecular classifier that accurately distinguishes ALS from healthy controls
- Outline the machine‑learning framework built on iPSC and patient spinal‑cord transcriptomes, emphasizing feature interpretability and reproducible performance across independent ALS cohorts
- Highlight the implications of these findings for developing mechanism‑anchored biomarkers and identifying novel therapeutic targets in ALS
